She was the concubine of Liu Chang (Southern Han), who ruled in 958–972. As the Emperor was not interested in politics, he left the state affairs to Lu Qiongxian, who managed them with the eunuchs Gong Chengshu and Chen Yanshou.

盧瓊仙在劉晟在位時已經在後宮任女官，劉晟於乾和年間封她及黃瓊芝為女侍中。劉鋹繼位後，政事都委託她與宦官龔澄樞處理，後來另一位宦官陳延壽推薦女巫樊胡子（一作樊胡）到宮中，稱玉皇大帝派她來授劉鋹為「太子皇帝」，盧瓊仙、龔澄樞、陳延壽是玉皇大帝派遣來輔助劉鋹，不可以因有過錯而治罪。

南漢滅亡後，盧瓊仙下落不見記載。